Dr. Muhammad Rafiq

Ph.D (South Korea)
Assistant Professor/Officer In-Charge

Phone Office: +92-062-9255703 Cell: +92-340-6299992
Email: mrafiq@cuvas.edu.pk

Biography:

Dr. Muhammad Rafiq, is working as an Assistant Professor/Officer In-Charge (BPS-19) in the Department of Physiology & Biochemistry, Faculty of Bio-Sciences, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Punjab, Pakistan. He has completed his M.Sc in 2008 major subject as Biochemistry from Bahauddin Zakariya University Multan. Dr. Muhammad Rafiq completed his PhD in Biochemistry from Kongju National University, Republic of Korea on 28th Aug 2015. The title of his PhD thesis was “Isolation, Synthesis, Enzyme Inhibition Analysis and Kinetic Investigation of Bioactive Compounds”. During his PhD studies he has published more than twenty five research articles in well reputed international journals with good impact factors. He has produced anti-tyrosinase inhibitors from both natural and synthetic sources. A patent for the invention has been registered at the Korean Intellectual property office, Republic of Korea. He has presented his scientific work in 14 International conferences including U.S.A, Korea & Poland. He has served the Islamia University of Bahawalpuras an Assistant Professor for two years and G. C. University Faisalabad, Layyah campus for one year.

Area of Interest:

  • Cosmetic material development.
  • Cosmetics preservatives isolations.
  • Skin whitening agents using tyrosinase inhibitors.
  • Hypo and Hyper-pigmentation.
  • Anti-wrinkle agents.
  • Anti-diabetic study.
  • Anti-Alzheimer’s drug screening employing AChE inhibition bioassay.
  • Anti-ulcer agents using Urease inhibitors.
  • Enzymatic Assay and Kinetic Investigations.

Training and Courses:

Two days In-Service competency enhancement training program for young University Faculty at Cholistan University of Veterinary & Animal Sciences, Bahawalpur in collaboration with CEPA.

Book Chapter:

  Muhammad Saleem, Muhammad Rafiq, Muhammad Hanif. Chapter Published in “Reviews in Fluorescence” Issue 2016. Springer

Patent:

Title of Invention; Novel 1,2,4-Triazole Compound and Pharmaceutical Composition for Inhibiting Urease Comprising the Same. Patent No. 10-1984129

Publications:

  • Muhammad Rafiq, Yasir Nazir, Zaman Ashraf, Hummera Rafique, Samina Afzal, Amara Mumtaz, Mubashir Hassan, Anser Ali, Khurram Afzal, Muhammad Rizwan Yousuf, Muhammad Saleem, Katarzyna Kotwica-Mojzych and Mariusz Mojzych, Synthesis, computational studies, tyrosinase inhibitory kinetics and antimelanogenic activity of hydroxy substituted 2-[(4-acetylphenyl)amino]-2- oxoethyl derivatives, J Enzyme Inhib Med Chem, 2019, VOL. 34, NO. 1, 1562–1572, (I.F = 4.02)
  • Anser Ali, Zaman Ashraf, Muhammad Rafiq, Ajeet Kumar, Farukh Jabeen, Goon Joon Lee, Fahad Nazir, Mushtaq Ahmed, Myungchull Rhee and Eun Ha Choi, Novel Amide Derivatives as Potent Tyrosinase Inhibitors; In-vitro, In-vivo Antimelanogenic Activity and Computational Studies, Medicinal Chemistry, 2019, 15, 1-14. (I.F = 2.53)
  • Muhammad Hanif, Fariha Kanwal, Muhammad Rafiq, Mubashir Hassan, Muhammad Mustaqeem, Sung-Yum Seo, Yunlong Zhang, Changrui Lu, Ting Chen, Muhammad Saleem, Symmetrical Heterocyclic Cage Skeleton: Synthesis, Urease Inhibition Activity, Kinetic Mechanistic Insight, and Molecular Docking Analyses, Molecules 2019, 24, 312. (I.F 3.09)
  • Muhammad Hanif, Muhammad Rafiq, Muhammad Saleem, Muhammad Mustaqeem, Saba Jamil, Muhammad Ramzan Saeed Ashraf Janjua, Chromogenic and fluorogenic detection of copper ions in the solution and intracellular media, J Chin Chem Soc. 2018;1–6.
  • Muhammad Saleem, Muhammad Rafiq, Yeon Ki Jeong, Dae Won Chod, Chong-Hyeak Kim, Sung-Yum Seo, Chang-Shik Choi, Seong-Karp Hong and Ki Hwan Lee, Facile Synthesis, Crystal Structure, DFT Calculation and Biological Activities of 4-(2 fluorophenyl)-3-(3-methoxybenzyl)-1H-1,2,4-triazol-5(4H)-one (5), Med. Chem, (2018), 14: 1–9. (I.F 2.93)
  • Muhammad Saleem, Muhammad Rafiq, Muhammad Hanif, Muhammad Ashraf Shaheen, Sung‑Yum Seo, Brief Review on Fluorescent Copper Sensor Based on Conjugated Organic Dyes, J Fluoresc, 28(1), 97-16, 2018.(I.F 1.6)
  • Zaman Ashraf, Muhammad Rafiq, Humaira Nadeem, Mubashir Hassan, Samina Afzal, Muhammad Waseem, Khurram Afzal, Jalifah Latip. Carvacrol derivatives as mushroom tyrosinase inhibitors; synthesis, kinetics mechanism and molecular docking studies, Plos One, 2017; 12(5), (I.F 3.54)
  • Pervaiz Ali Channar, Aamer Saeed, Fayaz Ali Larik, Muhammad Rafiq, Zaman Ashraf, Farukh Jabeen, Tanzeela Abdul Fattah, Synthesis, computational studies and enzyme inhibitory kinetics of substituted methyl[2-(4-dimethylamino-benzylidene)-hydrazono)-4-oxo-thiazolidin-5 ylidene]acetates as mushroom tyrosinase inhibitors, Bioorg. Med. Chem, 2017; 25(21), 5929-5938, (I.F 2.93)
  • Subaika Mahmood, Toseef Fatima, Hina Zulfaqar, Romana Saher, Muhammad Rafiq, Abdul Rehman, Rongji Dai, Muhammad Ashfaq, Murtaza Hasan, Meta-analysis of dragon’s blood resin extract as radio-protective agent, Journal of Coastal Life Medicine 2017; 5(9): 409-416, (I.F 1.2).
  • Anser Ali, Zaman Ashraf, Naresh Kumar, Muhammad Rafiq, Ji hoon Park, Farukh Jabeen, Ki Hong Choi, Seung Hyun Lee, Sung-Yum Seo, Eun Ha Choi, Pankaj Attri. Influence of the plasma activated compounds on the melanogenesis and tyrosinase activity. Scientific Reports. DOI: 10.1038/srep21779. (I.F= 5.22)
  • Muhammad Rafiq, Muhammad Saleem, Muhammad Hanif, Farukh Jabeen, Sung-Yum Seo, Sung Kwon Kang, Ki Hwan Lee. Facile synthesis, biological evaluation and molecular docking studies of novel substituted azole derivatives, Journal of Molecular Structure 1138 (2017) 177-191. (I.F=1.78)
  • Mariusz Mojzych, Paweł Tarasiuk, Katarzyna Kotwica-Mojzych, Muhammad Rafiq, Sung-Yum Seo, Michal Nicewicz, Emilia Fornal. Synthesis of chiral pyrazolo[4,3-e][1,2,4]triazine sulfonamides with tyrosinase and urease inhibitory activity. J Enzyme Inhib Med Chem, 2016; 32(1), 99-105(I.F 4.29)
  • Qamar Abbas,Muhammad Saleem, Abdul Rehman Phull, Muhammad Rafiq, Mubashir Hassan, Ki-Hwan Leeand Sung-Yum Seo, Green Synthesis of Silver Nanoparticles using Bidens Frondosa Extract and their Tyrosinase Activity.Iranian Journal of Pharmaceutical Research (2017), 16 (2):760-767.(I.F = 1.40)
  • Muhammad Saleem, Muhammad Rafiq, Muhammad Hanif. Organic Material Based Fluorescent Sensor for Hg2+: a Brief Review on Recent Development. J. Fluoresc.2016; 27(1), 31-58, (I.F= 1.6)
  • Muhammad Saleem, Muhammad Rafiq, Sung-Yum Seo, Ki Hwan Lee, Acetylcholinesterase immobilization, characterization and comparison of porous silicon immobilized enzyme activity with the free counterpart. Bioscience Reports Feb 02, 2016; DOI: 10.1042/BSR20150154. (I.F 2.9)
  • Aamer Saeed, Shamsul Mahmood, Muhammad Rafiq, Zaman Ashraf, Farukh Jabeen,Sung-Yum Seo. Iminothiazoline-sulfonamide hybrids as Jack Bean Urease inhibitors; Synthesis, kinetic mechanism and computational molecular modeling. Chem Biol Drug Des. (2016), 87, 434–443. (I.F 2.8)
  • Muhammad Rafiq, Muhammad Saleem, Muhammad Hanif, Kang Sung Kwon, Sung-Yum Seo, Ki Hwan Lee, Synthesis, structural elucidation, bioevaluation, optical, thermal and kinetic studies of Schiff base derivatives, Arch Pharm Res.(2016), 39, 161-171. (I.F 2.49)
  • Zaman Ashraf, Muhammad Rafiq, Sung-Yum Seo, Kang Sung Kwon, Mustafeez Mujtaba Babar, Najam-us-Sahar Sadaf Zaidi, Kinetic and in silico studies of novel hydroxy-based thymol analogues as inhibitors of mushroom tyrosinase, Eur. J. Med. Chem.(2015), 98, 203-211. (I.F 4.51).
  • Zaman Ashraf, Muhammad Rafiq, Sung-Yum Seo, Mustafeez Mujtab Babar, Najam-us-Sahar Sadaf  Zaidi­­­, Synthesis, kinetic mechanism and docking studies of vanillin derivatives as inhibitors of mushroom tyrosinase, Bioorg. Med. Chem, (2015), 23: 5870–5880. (I.F 2.93)
  • Muhammad Rafiq, Muhammad Saleem, Muhammad Hanif, Qamar Abbas,  Ki-Hwan Lee, Sung-Yum Seo, Acetylcholinesterase Inhibition Activity of Some Quinolinyl Substituted Triazolothiadiazole Derivatives, Russian Journal of Bioorganic Chemistry. (2015), 41(2): 195-202. (I.F 0.66)
  • Zaman Ashraf, Muhammad Rafiq, Sung-Yum Seo, Mustafeez  Mujtaba Babar, Najam-us-Sahar Sadaf Zaidi, Design, synthesis and bioevaluation of novel umbelliferone analogues as potential mushroom tyrosinase inhibitors, J Enzyme Inhib Med Chem, 2014; 30(6), 874-883. (I.F 4.29)
  • Muhammad Saleem, Muhammad Rafiq, Sung-Yum Seo, Ki Hwan Lee, Influence of acetylcholinesterase immobilization on the photoluminescence properties of mesoporous silicon surface, Applied Surface Science, (2014), 308, 148–154. (I.F 3.38)
  • Muhammad Saleem, Seon-Mi Yu, Muhammad Rafiq, Song-Ja Kim, Sung-Yum Seo and Ki Hwan Lee, Synthesis, Crystal Structure, Anti-inflammatory and Anti-hyperglycemic Activities of Novel 3,4-Disubstituted 1,2,4-Triazol-5(4H)-one Derivatives, Med. Chem, (2014), 10(8): 810-823.(I.F 2.33)
  • Muhammad Rafiq, Shruti S. Sancheti, Sandesh A. Sancheti, Hae-Ran Kim, Young-Han You and Sung-Yum Seo, Antihyperglycemic and antioxidant activities of Rhododendron schlippenbachii maxim. Bark and its various fractions, J. Med. Plants Res.  (2013), 7(12): 713-719.
  • Muhammad Rafiq, Muhammad Saleem, Muhammad Hanif, Muhammad Rizwan Maqsood, Nasim Hasan Rama, Ki-Hwan Lee, and Sung-Yum Seo, Synthesis and Biological Activities of Some New 3,6-Disubstituted 1,2,4-Triazolo[3,4-b]1,3,4-thiadiazole Derivatives, Bull. Korean Chem. Soc. (2012), 33(12): 3943-3949. (I.F 0.79)
  • Muhammad Saleem, Muhammad Rafiq, Muhammad Hanif, Nasim Hasan Rama, Sung-Yum Seo, and Ki-Hwan Lee, Synthesis, Urease and Acetylcholine Esterase Inhibition Activities of Some 1,4-Disubstituted Thiosemicarbazides and their 2,5-Disubstituted Thiadiazoles, Bull. Korean Chem. Soc. (2012), 33(8): 2741-2747. (I.F 0.79)
  • Muhammad Rizwan Maqsood, Muhammad Hanif, Muhammad Rafiq, Muhammad Saleem, Sumera Zaib, Aftab Ahmed Khan, Mazhar Iqbal, Jamshed Iqbal, Nasim Hasan Rama, Sung-Yum Seo, and Ki-Hwan Lee, Some Pyridyl- and Thiophenyl- Substituted 1,2,4-Triazolo[3,4-b]1,3,4-thiadiazole Derivatives as Potent Antibacterial, Bull. Korean Chem. Soc. (2012), 33(12): 4180-4184. (I.F 0.79)

Crystal Reports

  • Muhammad Hanif, Muhammad Rafiq, Muhammad Saleem,Ghulam Qadeer and Wai-Yeung Wong; Crystal structure of 1-(2,6-Dichlorophenyl)indolin-2-one: Acta Cryst., (UK), E65, o583, 2009.
  • Muhammad Rafiq, Muhammad Saleem,Ghulam Qadeer and Wai-Yeung Wong; Crystal structure of 4-Benzyloxy-3-methoxybenzonitrile: Muhammad Hanif, Acta Cryst., (UK), E65, o572, 2009.
  • Muhammad Rafiq,Muhammad Hanif, Ghulam Qadeer, Sauli Vuoti and Juho Autio; Crystal structure of (E)-1-(4-Aminophenyl) ethanone Oxime: Acta Cryst., (UK), E64, o2173, 2008.
  • Muhammad hanif, Ghulam Qadeer, Nasim Hasan rama, Muhammad Rafiq and Ales Ruzicka;Crystal Structure of  3-Hydroxybenzohydrazide; Acta Cryst., (U.K).E63, o4829, 2007.

Conference and Meetings:

  • Muhammad Rafiq, Muhammad Saleem, Lee KH, Seo S-Y (Dec 14~18. 2013) Synthesis, characterization, acetylcholinesterase inhibition, antioxidant and antibacterial studies of 4-amino-5-aryl-3H-1,2,4-triazole-3-thione analogues and their 3,6-disubstituted 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole derivatives, ASCB (American Society for Cell Biology), (New Orleans, USA).
  • Seong G, Muhammad R, Muhammad S, Lee KH, Seo SY (Dec 14~18. 2013) Synthesis, Acetylcholinesterase Inhibition and Anti-hyperglycemic Activities of Some Substituted Sulfonamide Derivatives, ASCB (American Society for Cell Biology), (New Orleans, USA).
  • Kim SN, Muhammad R, Seo SY (Dec 14~18. 2013) Separation and analysis of bioactive peptide from serum of Sus scrofa domesticus, ASCB (American Society for Cell Biology), (New Orleans, USA).
  • Muhammad rafiq, Ki Hwan Lee, Muhammad saleem, Seo Sung-Yum (Oct 17~19. 2012) Synthesis and biological activities of some new 3,6-Disubstituted 1,2,4-Triazolo[3,4-b]1,3,4-thiadiazole Derivatives, Korean chemical society (Bexco, Busan, korea).
  • Muhammad saleem, Ki Hwan Lee,Muhammad rafiq, Seo Sung-Yum (Oct 17~19. 2012) Synthesis, urease and acetylcholinesterase inhibition activities of some 1,4-Disubstituted thiosemicarbazides and their 2,5-Disubstituted thiadiazoles, Korean chemical society (Bexco, Busan, korea).
  • Muhammad rafiq, Seo Sung-Yum (Oct 15~17. 2014) Microwave assisted synthesis and biological activities of novel Schiff base derivatives, Korean chemical society (Kimdaejung Convention Center, Gwangju, korea).
  • Muhammad rafiq, Seo Sung-Yum (Oct 15~17. 2014) Synthesis of quinolinyl substituted triazolothiadiazole derivatives and their bioassay, Korean chemical society (Kimdaejung Convention Center, Gwangju, korea).
  • Muhammad rafiq, Seo Sung-Yum (Oct 15~17. 2014) α-Glucosidase and acetylcholinesterase inhibition activities of novel sulfonamide derivatives, Korean chemical society (Kimdaejung Convention Center, Gwangju, korea).
  • Rafiq Muhammad, Seo Sung-Yum (Oct 23~24. 2014) Facile synthesis, crystal structure and biological activities of 4-(2-fluorophenyl)-3-(3-methoxybenzyl)-1H-1,2,4-triazole-5(4H)-one, Proceedings of the fall international convention of the pharmaceutical society of korea (Hotel Hyundai, Gyeongju, Gyeongsangbuk-do, Korea).
  • Rafiq Muhammad, Jo Su-eon, Lim Jin-Hye, Seo Sung-Yum (Oct 23~24. 2014) Biological assay of synthetic triazolothiadiazole derivatives, Proceedings of the fall international convention of the pharmaceutical society of korea (Hotel Hyundai, Gyeongju, Gyeongsangbuk-do, Korea).
  • Muhammad Rafiq, Microwave assisted synthesis, in vivo anti-inflammatory and in vitro anti-oxidant activities of novel substituted Schiff base derivatives. 2nd International Conference on Recent Trend in Chemistry at AIOU, Islamabad Pakistan.