Dr. Arslan Sehgal

Assistant Professor
Department of Genomics and Bioinformatics

Contact:
Email: arslansehgal@yahoo.com
            arslansehgal@cuvas.edu.pk
Office Address: Department of Genomics and Bioinformatics

Biography:

Dr. Arslan Sehgal, is an Assistant Professor in the Department of Genomics and Bioinformatics, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. Dr. Sehgal completed his PhD in 2019 from Chinese Academy of Sciences. Dr. Sehgal intends to design active biomolecules by utilizing in silico analyses and also develop novel approaches to scrutinize the novel compounds against auto(mito)phagy, cancer and neurodegenerative disorders. He works on immunoinformatics analyses to reveal potential epitope-based peptide vaccines. He has expertise in computational phylogenetics analyses and evolutionary biology. He has expertise to verify the computationally scrutinized compounds in wet lab experiments.
He served in University of Okara and The Islamia University of Bahawalpur. He has authored/co-authored fifty-six (56) research/review articles (having ~220 IF) in peer reviewed journals and two (02) complete book as principle and corresponding author. For his contributions in the field, he was awarded with Research Productivity Award for the year of 2015, 2016 and 2017 by CUI, and CAS-TWAS president fellowship award 2015. Moreover, in 2018, he was honored with the Excellent International Student of UCAS 2018.

Area of Interest:

• Development of bioassays to screen drugs against cancer and mitochondrial diseases
• Drug discovery against neurological disorders
• Subtractive genomics, Reverse vaccinology and comparative genomics for drug and vaccine development
• Immunoinformatics and epitope-based vaccine design
• Mitochondrial Biogenesis and auto(mito)phagy

Trainings/Courses/ Workshops
 

• One month training of “National Faculty Development Program 2020 - HEC” under National Academy of Higher Education (NAHE), Higher Education Commission of Pakistan.

Publications

Corresponding Author

• Pharmacological Progress of Mitophagy Regulation. Current Neuropharmacology, 2023(IF: 7.72).
• Epidemiological studies of sleep disorder in educational community of Pakistani population, its major risk factors and associated diseases. PloS one 2022, 17 (4), e0266739 (IF: 3.14)
• Epitope-based peptide vaccine design and elucidation of novel compounds against 3C like protein of SARS-CoV-2. Plos one 2022, 17.3 e0264700 (IF: 3.14)
• Immunoinformatics and Molecular Docking Studies Predicted Potential Multiepitope-Based Peptide Vaccine and Novel Compounds against Novel SARS-CoV-2 through Virtual Screening. BioMed Research International, 2021, (IF: 3.411)
• The life cycle and in silico elucidation of non-structural replicating proteins of HCV through a pharmacoinformatics approach. Combinatorial Chemistry & High Throughput Screening, 25 (4), 689-701 (IF: 1.339)
• Anti-aging natural compounds and their role in the regulation of metabolic pathways leading to longevity. Mini Reviews in Medicinal Chemistry, 2021, (IF: 3.860)
• Determine the potential Epitope based Peptide Vaccine against novel SARS-CoV-2 targeting structural proteins using immunoinformatics approaches. Frontiers in Molecular Biosciences, 2020, 7, 227 (IF: 5.246)
• In Silico identification of angiotensin-converting enzyme inhibitory peptides from MRJP1. PloS One, 2020, 15 (2), e0228265. (IF: 3.240)
• Ligand-Based Pharmacophore Modeling and Virtual Screening to Discover Novel CYP1A1 Inhibitors. Current Topics in Medicinal Chemistry, 2019, 19 (30), 2782-2794. (IF: 3.295)
• Pharmacoinformatics and molecular docking reveal potential drug candidates against Schizophrenia to target TAAR6. Journal of Cellular Physiology, 2019, 234 (8), 13263-13276. (IF: 6.384)
• Immunoinformatics and molecular docking studies reveal potential Epitope based Peptide Vaccine against DENV-NS3 Protein. Journal of Theoretical Biology, 2018, 459, 162-170. (IF: 2.691)
• Current Therapeutic Molecules and Targets in Neurodegenerative Diseases Based on in silico Drug Design. Current Neuropharmacology, 2018, 16(6), 649-663. (IF: 7.360)
• Pharmacoinformatics and Molecular Docking Studies Reveal Potential Novel Compounds Against Schizophrenia by Target SYN II. Combinatorial Chemistry & High Throughput Screening 2018, 21(3), 175-181. (IF: 1.339)
• Pharmacoinformatics and molecular docking studies reveal potential novel Proline Dehydrogenase (PRODH) compounds for Schizophrenia inhibition. Medicinal Chemistry Research 2017, 26(2), 314-326. (IF: 1.965)
• Pharmacoinformatics, Adaptive Evolution, and Elucidation of Six Novel Compounds for Schizophrenia Treatment by Targeting DAOA (G72) Isoforms. BioMed Research International, 2017,Article ID 5925714, doi:10.1155/2017/5925714. (IF: 3.411)
• Pharmacoinformatic and molecular docking studies reveal potential novel antidepressants against neurodegenerative disorders by targeting HSPB. Drug Design Development and Therapy 2016, 10, 1605 (IF: 4.162)
• Comparative Modeling, Molecular Docking, and Revealing of Potential Binding Pockets of RASSF2; a Candidate Cancer Gene. Interdisciplinary Sciences: Computational Life Sciences, 2017, 9(2), 214-223. (IF: 2.233)

Principal Author

• Molecular docking analyses of CYP450 monooxygenases of Tribolium castaneum (Herbst) reveal synergism of quercetin with paraoxon and tetraethyl pyrophosphate: in vivo and in silico studies. Toxicology Research, 2020, tfaa023, https://doi.org/10.1093/toxres/tfaa023. (IF: 3.524)
• Adaptive Evolution and elucidating the potential inhibitor against Schizophrenia to target DAOA (G72) Isoforms. Drug Design Development and Therapy 2015, 9, 3471 (IF: 4.162)
• Pharmacoinformatics elucidation of potential drug targets against migraine to target ion channel protein KCNK18. Drug Design Development and Therapy 2014 8, 571-581. (IF: 4.162)
• Tumor Necrosis Factor Receptor Superfamily 10B (TNFRSF10B), An insight from structure modeling to virtual screening for designing drug against head and neck cancer. Theoretical Biology and Medical Modeling 2013, 10:38. (IF: 2.432)
• Structural, phylogenetic and docking studies of D-amino acid oxidase activator (DAOA), a candidate schizophrenia gene. Theoretical Biology and Medical Modeling 2013, 10:1. (IF: 2.432)

Co-Author

• The multifaceted regulation of mitophagy by endogenous metabolites. Autophagy, 2022, 18 (6) 1216-1239 (IF: 16.016)
• Synthesis and characterization of copper oxide nanoparticles: its influence on corn (Z. mays) and wheat (Triticum aestivum) plants by inoculation of Bacillus subtilis. Environmental Science and Pollution Research, 2023 30 (13) 37370-37385 (IF: 5.190)
• Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy. Redox Biology, 2020, 101661 (IF: 11.799)
• Identification of effective membrane efflux transporters against β‐amyrin through molecular docking approach. Journal of Chemical Technology & Biotechnology, 2019 94 (9), 2869-2875. (IF: 3.174)
• STING directly activates autophagy to tune the innate immune response. Cell Death and Differentiation 2019, 26 (9), 1735-1749 (IF: 15.828)
• Prevalence of Extended Spectrum β-Lactamases in Multi-drug Resistant Pseudomonas aeruginosa from Diabetic Foot Patients. Endocrine, Metabolic & Immune Disorders Drug Targets 2019, 19(4), 443-448 doi.org/10.2174/1871530319666181128095753. (IF: 2.895)
• Formulation and Characterization of a Self-Emulsifying Drug Delivery System (SEDDS) of Curcumin for the Topical Application in Cutaneous and Mucocutaneous Leishmaniasis. Current Topics in Medicinal Chemistry 2018, 18(18), 1603-1609. (IF: 3.295)
• In Silico characterization and In-Vivo validation of Albiziasaponin-A, Iso-Orientin and Salvadorin using a rat model of Alzheimer’s disease. Frontiers in Pharmacology 2018, 9, 730. (IF: 5.810)
• Comparative in silico analyses of Cannabis sativa, Prunella vulgaris and Withania somnifera compounds elucidating the medicinal properties against rheumatoid arthritis. Journal of Molecular Graphics and Modelling 2017, 74, 296-304 (IF: 2.518)
• Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine‐tune hypoxic mitophagy. EMBO reports, 2017, 18(3), 495-509 p.e201643309. (IF: 8.807)
• Mitophagy Receptors Sense Stress Signals and Couple Mitochondrial Dynamic Machinery for Mitochondrial Quality Control. Free Radical Biology and Medicine 2016 100, 199-209. (IF: 7.376)
• Regulatory cascade of neurological loss and glucose metabolism. CNS & Neurological Disorders - Drug Targets 2014 13(7), 1232-1245. (IF: 4.388)

Books edited, Book chapters or monographs published

• Quick Guideline for Computational Drug Design. 2018 Bentham Science Publishers (First and Corresponding author) (ISBN: 978-1-68108-604-0)
• Quick Guideline for Computational Drug Design Revised Edition 2021 Bentham Science Publishers (First and Corresponding author) (ISBN: 978-981-4998-70-3)

Awards or Distinctions

• 1st position in a Poster Competition in Conference “Innovations in Chemistry, Biochemistry, Biotechnology and Bioinformatics, 17-21 December 2022”
• 1st position in a Poster Competition in Conference “New Trends in Biological Sciences, 16-17 January 2022”
• 2nd Position in a Poster Competition in Conference “Advances in Bioinformatics in Post Genomic Era, 6th November 2014”
• Research Productivity Award 2015, CIIT (CUI)
• Research Productivity Award 2016, CIIT (CUI)
• Research Productivity Award 2017, CIIT (CUI)
• Excellent International Student of UCAS 2018
• HEC approved Supervisor

Conferences attended/presented papers or posters

• 9th Biennial PSBMB Conference on Advances in Biochemistry and Molecular Biology 17-20 December 2008, Rawalpindi Pakistan
• 31st Pakistan Congress of Zoology, 19-21 April 2011, Muzaffarabad, Kashmir Pakistan
• National Symposium on Computational Science, 8th November 2012, Islamabad Pakistan
• 2nd Annual Workshop on Computational tools, 20-25 October 2013, Islamabad Pakistan
• 2nd Conference on Emerging trends in Bioinformatics and Computational Biology, 7th June 2014, Islamabad Pakistan
• Conference on Advances in Bioinformatics in Post Genomic Era, 6th November 2014, Islamabad Pakistan
• World Life Science Conference, 1-4 November 2016, Beijing China
• Mitochondria Quality Control, 2-6 July 2017, Xian China
• Global Young Scientist Summit, 21-26 January 2018, Singapore
• The 3rd Big Data Forum for Life and Health Sciences, 11-14 October, Beijing China
• World Life Science Conference, 26-29 October 2018, Beijing China
• 1st International Conference on Emerging Trends of Inter-disciplinary Research in Biomedical Sciences, 10-11 December 2020, Okara, Pakistan
• Recent Trends in Genome Editing, 26 October 2021, Okara, Pakistan
• New Trends in Biological Sciences, 21-22 March 2022, Okara, Pakistan
• 1st International Conference on Emerging Trends of Inter-disciplinary Research in Biomedical Sciences, 10-11 December 2020, Okara, Pakistan (Organizing Team, Focal Person Publication)
• New Trends in Biological Sciences, 21-22 March 2022, Okara, Pakistan (Organizing Team)
• Innovations in Chemistry, Biochemistry, Biotechnology and Bioinformatics, 17-21 December 2022” (Organizing Team)
• Sehgal SA, New Trends in Biological Sciences, 21-22 March 2022, University of Okara, Pakistan (Invited Speaker)
• Sehgal SA, Recent Trends in Genome Editing, 26 October 2021, University of Okara, Pakistan (Invited Speaker)
• Sehgal SA, New Trends in Biological Sciences, 16-17 January 2023, University of Okara, Pakistan (Invited Speaker)
• Sehgal SA, Innovations in Chemistry, Biochemistry, Biotechnology and Bioinformatics, 17-21 December 2022, The Islamia University Bahawalpur, Pakistan (Invited Speaker)