Dr. Arslan Sehgal
Assistant Professor
Department of Genomics and Bioinformatics — Faculty of Animal Production and Technology
Biography
Dr. Arslan Sehgal is an Assistant Professor in the Department of Genomics and Bioinformatics, Cholistan University of Veterinary and Animal Sciences (CUVAS), Bahawalpur, Pakistan. His research expertise lies in computer-aided drug design, structural bioinformatics, molecular docking, molecular dynamics simulations, virtual screening, genomics, metagenomics, and computational vaccine design.
He completed his PhD in Cell Biology (Bioinformatics) from the University of Chinese Academy of Sciences, China, in 2019, where his doctoral research focused on identifying novel compounds targeting the LC3–FUNDC1 protein–protein interaction for inhibition of mitophagy, integrating computational screening with experimental validation.
Dr. Sehgal has published more than 72 research and review articles and has an h-index of 26. His research interests include structure-based drug discovery, genomics-driven therapeutic and vaccine discovery, reverse vaccinology, immunoinformatics, whole-genome and exome sequencing, variant analysis, and microbiome research using 16S rRNA sequencing.
He also has experience in laboratory techniques including DNA/RNA extraction, PCR, qPCR, ELISA, gel electrophoresis, and Western blotting. His current work focuses on integrating bioinformatics, genomics, and computational biology to address problems in drug discovery, infectious diseases, cancer, neurological disorders, and animal health research.
Research interests
Educational information
| Year | Degree | Board / University |
|---|---|---|
| 2019 | Ph.D. Cell Biology (Bioinformatics) | Chinese Academy of Sciences, Beijing, China |
| 2013 | MPhil Bioinformatics | International Islamic University Islamabad |
| 2010 | BS Bioinformatics | Government College University Faisalaabd |
Academic experience
| From | To | Post held | Organisation |
|---|---|---|---|
| Feb 2015 | Sep 2015 | Lecturer | COMSATS University Islamabad Sahiwal Campus |
| Aug 2020 | Aug 2021 | Assistant Professor (IPFP) | University of Okara |
| Apr 2022 | Apr 2024 | Lecturer | Islamia University of Bahawalpur |
| Apr 2024 | To Date | Assistant Professor | Cholistan University of Veterinary and Animal Sciences |
Publications
- — Structure-based virtual screening, multi-score docking, and molecular dynamics simulation of novel small molecules targeting the epidermal growth factor receptor for potential management of oral squamous cell carcinoma, In Silico Pharmacology2026
- — Exploring the Therapeutic Potential of Cannabis Constituents in Parkinson's Disease: Insights from Molecular Docking Simulations, Medinformatics2026
- — Network pharmacology and integrative bioinformatics analyses identify PDE1A as a key target of pirfenidone in idiopathic pulmonary fibrosis, PlosOne2026
- — Computational exploration of Withania coagulans-derived natural inhibitors targeting HMG-CoA reductase: A pharmacokinetic, docking and molecular dynamics study for cholesterol regulation in Mus musculus, Pakistan Journal of Pharmaceutical Sciences2026
- — Network pharmacology-based identification of potential drug targets and bioactive compounds in Lycii Fructus (Gouqizi) for the therapeutics of Parkinson’s disease, Frontiers in Pharmacology2026
- — The long noncoding RNA SNHG12 defines KEAP1 stability and ferroptosis susceptibility by targeting E3 ligase TRIM25, Journal of Biological Chemistry2025
- — Bioinformatics approaches in upgrading microalgal oil for advanced biofuel production through hybrid ORF protein construction, Ihtesham Arshad, Muhammad Ahsan, Imran Zafar, Muhammad Sajid, Sheikh Arslan Sehgal, Waqas Yousaf, Amna Noor, Summya Rashid, Somenath Garai, Meivelu Moovendhan, Rohit Sharma2025
- — In silico Identification and Computational Screening of Potential AFP Inhibitors Against Liver Cancer, Medicinal Chemistry2025
- — In Silico Identification of Novel Compounds as Anthelmintics Against Haemonchus contortus Through Inhibiting β-Tubulin Isotype 1 and Glutathione S-Transferase, Animals2025
- — Genetic insights into obesity: in silico identification of pathogenic SNPs in MBOAT4 gene and their structural molecular dynamics consequences, Journal of Biomolecular Structure and Dynamics2024
- — In silico identification and virtual screening to discover potent therapeutic phytochemicals against CMT2A, Journal of the Indian Chemical Society2024
- — Computational Advancement towards the Identification of Natural Inhibitors for Dengue Virus: A Brief Review, Combinatorial Chemistry & High Throughput Screening2024
- — Recent trends in computer-aided drug design for anti-cancer drug discovery, Current Topics in Medicinal Chemistry2023
- — In silico designing of multiepitope-based-peptide (MBP) vaccine against MAPK protein express for Alzheimer's disease in Zebrafish, Heliyon2023
- — Elucidation of novel compounds and epitope-based peptide vaccine design against C30 endopeptidase regions of SARS-CoV-2 using immunoinformatics approaches, Frontiers in Cellular and Infection Microbiology2023
- — Comprehensive in silico analyses of flavonoids elucidating the drug properties against kidney disease by targeting AIM2, PLoS One2023
- — Pharmacological progress of mitophagy regulation, Current Neuropharmacology2023
- — In silico elucidation of potential drug targets against oxygenase domain of Human eNOS Dysfunction, PLoS One2023
- — Synthesis and characterization of copper oxide nanoparticles: its influence on corn (Z. mays) and wheat (Triticum aestivum) plants by inoculation of Bacillus subtilis, Environmental Science and Pollution Research2023
- — The future of health diagnosis and treatment: an exploration of deep learning frameworks and innovative applications, Deep learning in personalized healthcare and decision support2023
- — The multifaceted regulation of mitophagy by endogenous metabolites, Autophagy2022
- — Epidemiological studies of sleep disorder in educational community of Pakistani population, its major risk factors and associated diseases, PLoS One2022
- — Epitope-based peptide vaccine design and elucidation of novel compounds against 3C like protein of SARS-CoV-2, PLoS One2022
- — The life cycle and in silico elucidation of non-structural replicating proteins of HCV through a pharmacoinformatics approach, Combinatorial chemistry & high throughput screening2022
- — Anti-aging natural compounds and their role in the regulation of metabolic pathways leading to longevity, Mini Reviews in Medicinal Chemistry2021
- — Quick Guideline for Computational Drug Design (Revised Edition), Bentham Sciences2021
- — Immunoinformatics and molecular docking studies predicted potential multiepitope‐based peptide vaccine and novel compounds against novel SARS‐CoV‐2 through virtual screening, BioMed research international2021
- — Determine the potential epitope based peptide vaccine against novel SARS-CoV-2 targeting structural proteins using immunoinformatics approaches, Frontiers in molecular biosciences2020
- — Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy, Redox Biology2020
- — Association of Virulence Genes with Antibiotic Resistance in Pakistani Uropathogenic E. coli Isolates, Combinatorial Chemistry & High Throughput Screening2020
- — Molecular docking analyses of CYP450 monooxygenases of Tribolium castaneum (Herbst) reveal synergism of quercetin with paraoxon and tetraethyl pyrophosphate: in vivo and in silico studies, Toxicology Research2020
- — In Silico identification of angiotensin-converting enzyme inhibitory peptides from MRJP1, PloS one2020
- — Ligand-based pharmacophore modeling and virtual screening to discover novel CYP1A1 inhibitors, Current Topics in Medicinal Chemistry2019
- — Identification of effective membrane efflux transporters against β‐amyrin through molecular docking approach, Journal of Chemical Technology & Biotechnology2019
- — STING directly activates autophagy to tune the innate immune response, Cell Death & Differentiation2019
- — Pharmacoinformatics and molecular docking reveal potential drug candidates against Schizophrenia to target TAAR6, Journal of cellular physiology2019
- — Prevalence of Extended-Spectrum β-Lactamases in Multi-drug Resistant Pseudomonas aeruginosa from Diabetic Foot Patients, Endocrine, Metabolic & Immune Disorders-Drug Targets2019
- — Immunoinformatics and molecular docking studies reveal potential epitope-based peptide vaccine against DENV-NS3 protein, Journal of theoretical biology2018
- — In-Silico Characterization and in-Vivo Validation of Albiziasaponin-A, Iso-Orientin, and Salvadorin Using a Rat Model of Alzheimer's Disease, Frontiers in Pharmacology2018
- — Formulation and characterization of a self-emulsifying drug delivery system (SEDDS) of curcumin for the topical application in cutaneous and mucocutaneous leishmaniasis, Current topics in medicinal chemistry2018
- — Current therapeutic molecules and targets in neurodegenerative diseases based on in silico drug design, Current neuropharmacology2018
- — Pharmacoinformatics and molecular docking studies reveal potential novel compounds against schizophrenia by target SYN II, Combinatorial chemistry & high throughput screening2018
- — In silico elucidation of potential drug target sites of the Thumb Index Fold Protein, Wnt-8b, Tropical Journal of Pharmaceutical Research2018
- — Quick guideline for computational drug design, Bentham Sciences2018
- — Comparative modeling, molecular docking, and revealing of potential binding pockets of RASSF2; a candidate cancer gene, Interdisciplinary Sciences: Computational Life Sciences2017
- — Comparative in silico analyses of Cannabis sativa, Prunella vulgaris and Withania somnifera compounds elucidating the medicinal properties against rheumatoid arthritis, Journal of Molecular Graphics and Modelling2017
- — Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine‐tune hypoxic mitophagy, EMBO reports2017
- — Pharmacoinformatics and molecular docking studies reveal potential novel Proline Dehydrogenase (PRODH) compounds for Schizophrenia inhibition, Medicinal Chemistry Research2017
- — Pharmacoinformatics, adaptive evolution, and elucidation of six novel compounds for schizophrenia treatment by targeting DAOA (G72) isoforms, BioMed research international2017
- — Possible Roles of the Pseudogenes of Salmonella typhimurium, Pakistan Journal of Zoology2016
- — Mitophagy receptors sense stress signals and couple mitochondrial dynamic machinery for mitochondrial quality control, Free Radical Biology and Medicine2016
- — Pharmacoinformatic and molecular docking studies reveal potential novel antidepressants against neurodegenerative disorders by targeting HSPB8, Drug design, development and therapy2016
- — Tobacco consequences oral health: a review article, Research and Reviews: A Journal of Toxicology2016
- — Adaptive evolution and elucidating the potential inhibitor against schizophrenia to target DAOA (G72) isoforms, Drug design, development and therapy2015
- — Pharmacoinformatics elucidation of potential drug targets against migraine to target ion channel protein KCNK18, Drug design, development and therapy2014
- — Regulatory cascade of neuronal loss and glucose metabolism, CNS & Neurological Disorders-Drug Targets2014
- — Molecular modeling and docking analysis of CYP1A1 associated with head and neck cancer to explore its binding regions, J Theoret Comput Sci2014
- — Genic microsatellite markers for genetic diversity of rust resistant wheat genotypes, Journal of Biochemical Technology2013
- — Tumor necrosis factor receptor superfamily 10B (TNFRSF10B): an insight from structure modeling to virtual screening for designing drug against head and neck cancer, Theoretical Biology and Medical Modelling2013
- — Structural, phylogenetic and docking studies of D-amino acid oxidase activator (DAOA), a candidate schizophrenia gene, Theoretical Biology and Medical Modelling2013
- — Molecular genetic characterization of rust in wheat genotypes, Asian Journal of Agricultural Sciences2012
- — Molecular characterization of wheat genotypes using SSR markers, International Journal Bioautomation2012
- — In silico Comparative Modeling of PapA1 and PapA2 Proteins Involved in Mycobacterium Tuberculosis Sulfolipid-1 Biosynthesis Pathway, International Journal Bioautomation2012
Conferences
| Year | Level | Country | City | Conference |
|---|---|---|---|---|
| 2022 | National | Pakistan | Okara | New Trends in Biological Sciences |
| 2021 | National | Pakistan | Okara | Recent Trends in Genome Editing |
| 2020 | International | Pakistan | Okara | 1st International Conference on Emerging Trends of Inter-disciplinary Research in Biomedical Sciences |
| 2018 | International | Singapore | Singapore | Global Young Scientist Summit |
| 2018 | International | China | Beijing | The 3rd Big Data Forum for Life and Health Sciences |
| 2018 | International | China | Beijing | World Life Science Conference |
| 2017 | International | China | Xian | Mitochondria Quality Control |
| 2016 | International | China | Beijing | World Life Science Conference |
| 2014 | National | Pakistan | Islamabad | 2nd Conference on Emerging trends in Bioinformatics and Computational Biology |
| 2014 | National | Pakistan | Islamabad | Conference on Advances in Bioinformatics in Post Genomic Era |
| 2013 | National | Pakistan | Islamabad | 2nd Annual Workshop on Computational tools |
| 2012 | National | Pakistan | Islamabad | National Symposium on Computational Science |
| 2011 | National | Pakistan | Kashmir | 31st Pakistan Congress of Zoology, 19-21 April 2011, Muzaffarabad, Kashmir Pakistan |
| 2008 | National | Pakistan | Rawalpindi | 9th Biennial PSBMB Conference on Advances in Biochemistry and Molecular Biology |
Awards
| Year | Awarding organisation | Description |
|---|---|---|
| 2022 | Islamia University of Bahawalpur | 1st position in a Poster Competition in Conference “Innovations in Chemistry, Biochemistry, Biotechnology and Bioinformatics, 17-21 December 2022” |
| 2022 | University of Okara | 1st position in a Poster Competition in Conference “New Trends in Biological Sciences, 16-17 January 2022” |
| 2020 | HEC | One month training of “National Faculty Development Program 2020 - HEC” under National Academy of Higher Education (NAHE), Higher Education Commission of Pakistan. |
| 2018 | Chinese Academy of Sciences, Beijing, China | Excellent International Student of UCAS 2018 |
| 2017 | COMSATS University Islamabad | Research Productivity Award 2017, CIIT (CUI) |
| 2016 | COMSATS University Islamabad | Research Productivity Award 2016, CIIT (CUI) |
| 2015 | COMSATS University Islamabad | Research Productivity Award 2015, CIIT (CUI) |
| 2014 | Quaid-e-Azam University | 2nd Position in a Poster Competition in Conference “Advances in Bioinformatics in Post Genomic Era, 6th November 2014” |
Research funding
| Year | Funding agency | Project | Amount (PKR) |
|---|---|---|---|
| 2021 | HEC | Elucidation of novel potential compounds againstAuto(mito)phagy by targeting LC3 and FUNDC1: in silico and in vitro studies | 1000000 |
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